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LCMS 2010A Advanced
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LCMS 2010A (Advanced) refined and enhanced for even higher sensitivity in mass spectrometry detection.

lcms 2010a
 
   
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Key Features

  • Revised ion source design. Orthogonal source geometry with an additional drying gas at the inlet of the capillary. Results in higher sensitivity and greater control of solvent adduct formation.
  • Revised electrospray probe design. Maintenance free design.
  • Revised ion optics. Enhanced ion transmission by further optimising the skimmer cone design at the entrance to the mass analyser.
  • Microbore compatibility for both ESI and APCI. Technological advances in probe design have expanded the operating range of both APCI and ESI without affecting sensitivity. APCI is now compatible with microbore flow rates (less than 50uL/minute) while ESI can operate with flow rates as high as 2mL/minute without requiring flow splitting
  • Mass directed purification support. PsiPort™ mass directed auto-purification software has been designed to help accelerate compound isolation and auto-purification by preparative LC/MS. The application software is web-based providing a generic solution to data review and data acquisition and has been designed to meet the needs of medicinal and synthetic chemists to track samples, fractions and associated data from MS and UV detectors. PsiPort™ also supports third party devices such as the Gilson 215 either as a fraction collector or autosampler.
  • Fast scanning electronics support 6000 amu/second (6000 data points per second) acquisition rates for fast chromatography applications. Peak widths of several seconds may be detected using fast scan rates to maintain spectrum quality without affecting the accuracy and precision of detection.
  • Multi-sequence mode support. Supports mixed mode analysis (switching between full scan acquisitions and selected ion monitoring), multiple acquisition conditions in a single analysis, simultaneous structural information and molecular weight confirmation in both positive and negative ion mode from a single injection and optimizes the response to both quantitation ions and confirmatory ions to minimize false positives and increase confidence in peak assignment.
  • Automatically controlled nebulizer gas flow.
  • Software-controlled syringe pump for simple calibration and infusion.
  • Unique Q-array™ (patent pending) ion guide. Q-array ion guide (patent pending) configuration is unique - three quadrupoles with different inscribed radii coupled with an octapole The Q-array™ precisely focuses ion delivery into the mass analyser. The ion optic design for the LCMS-2010A is the most innovative design in ion focussing technology. Using the Q-array™ (patent pending) and octapole RF guides to precisely focus ions to the mass analyser we deliver new limits of detection for LC.
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Unmatched Productivity

  • Supports the new standard in high throughput auto-injectors, the SIL-HT from Shimadzu (15 second injection cycle)
  • Automatic acquisition, processing and reporting through a single click of the mouse
  • High throughput micro-titre plate support.
  • Customised reporting for efficient and effective information management.
  • Streamlined data processing for third party software systems.
  • Automated export to knowledge systems.
  • Mass directed purification.
  • Multi-sequence mode capability maximizing MS information in a single run
Multi-sequence mode

  • Enhanced source design
  • The atmospheric pressure ion source now supports a counter gas flow to control adduct formation and enhance ion transmission of low polarity compounds. The counter gas flow not only enhances the desolvation processes but reduces the maintenance on the capillary inlet.
  • To reduce maintenance further and increase sensitivity the electrospray probe design has also been redesigned to take into account a stainless steel capillary.
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PsiPort Mass directed fraction collection control

  • PsiPort™ is a software application layer designed to help accelerate compound isolation and auto-purification with preparative LC/MS. It is specifically designed to provide an advantage in automated purification for life science and pharmaceutical scientists.
  • It is web-based providing a generic solution to data review and data acquisition using tool sets from Microsoft based on .net technology. Designed to meet the needs of medicinal and synthetic chemists to track samples, fractions and associated data from MS and UV detectors.
  • PsiPort™ also supports third part devices such as the Gilson 215 as a fraction collector or autosampler.
  • Streamlining data management is the driving force behind LabSolutions software providing full system security to help you achieve CFR 21 part 11 compliance and protect critical information to the fullest extent possible.
  • LabSolutions software includes full chromatogram and spectrum processing, integrated quantitation, library searching and library generation together with the most comprehensive reporting package ever designed for LCMS. The philosophy is simple; provide the best results.
  lcms 2010a close up
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One click approach

  • Automatically acquires, processes and reports from a single click of the mouse.
  • Redefines LCMS as a technique for all scientists.
PsiPort Key features

  • Access controls - Set user privileges for specific tasks using passwords
  • Integrated autotuning.
  • PDA support - provides additional data to compliment MS data.
  • Mass directed fraction control support.
  • Comprehensive support of Shimadzu LC products.
  • Compound binary file format includes all data, LCMS method information, tuning,instrument performance and results.
  • Fully customized reporting maximizes information yield and provides the most flexible environment available for LCMS.
  • Automatic data export to LIMS.
  • Comprehensive system checks carefully designed to protect the system and the samples.
  • System check to diagnose system faults and identify service intervals.
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Standard configuration

  • Mass range 10-2000u.
  • Maximum scan speed 6000 u/sec (centroid) or 4000 u/sec (profile).
  • Electrospray (ESI) and atmospheric pressure chemical ionization (APCI) probes are supplied as standard [electrospray flow rate range between 0.001-1mL/minute; atmospheric pressure chemical ionization flow rate range 0.005-2mL/minute].
Installation requirements

  • Temperature range between 18°C to 28°C.
  • Humidity between 40% - 70%.
  • Size W450mm - D725mm - H420mm
  • Weight 90kg (MS main unit only)
  • Gas supply - nitrogen at a maximum flow rate of 21.5 L/minute
Single vendor advantage

  • The family of products to support LC/MS are from one supplier - Shimadzu. This provides an advantage in integrating instrument control, addressing GLP requirements, providing flexibility in system design and a unified support for service and technical assistance.
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